We have developed near-quantitative synthetic protocols for the aqueous synthesis of rotaxanes and protein-mounted rotaxanes by employing efficient bioconjugation reactions.
We have developed rotaxanes that release cucurbituril, a contrast agent for an emerging NMR and MRI technology based on hyperpolarized xenon, in response to chemical and biochemical signals.
The convergence of sophisticated mechanically bonded molecular architectures with the stimulus-responsive properties of their underlying donor-acceptor recognition motifs has allowed us to prepare macromolecules that expand and contract (similar to the repeating units of muscle tissue) in response to a variety of energy sources, including electrochemical, thermal, and mechanical stimuli.
We have carried out ring-threading reactions inside of self-assembled molecular flasks based on metallo-organic coordination cages. The flasks are “gated” in the sense that they only allow the rings to enter in the presence of excessive ions, not unlike many ion channels in the membranes of living cells.
We systematically studied a series of semiconducting surfactants that can be co-assembled with ZnO into photoconducting inorganic-organic hybrid lamellar nanostructures by electrodeposition. We unconvered molecular design rules for controlling the long-range orientation of these nanoscuctures.
We have designed a series of oligorotaxanes in which the axle of the dumbbell adopts a well-defined folding pattern as it “snakes” its way through a series of rings. These compounds behave like accordions that can be mechanically unfolded and re-folded at the single-molecule level by the cantilever of an atomic force microscope.
We have developed a number of families of small-molecule p-type organic semiconductors for solution-processed photovoltaics, with the aim of understanding structure-property relationships for these materials. We have designed the compounds to self-assemble into structures that facilitate photocurrent generation in order to enhance the efficiency of these low-cost solar cells.